Our research is devoted to understanding the mechanisms underlying human cortical circuit development and dysfunction, with a focus on neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD), epilepsy, and intellectual disability. We are particularly interested in exploring how these conditions impact synaptic function, neuronal connectivity, and circuit dynamics.

We develop and utilize advanced human-based models, including stem cell-derived cortical organoids and transplantation platforms. By combining techniques such as optogenetics, electrophysiology, in situ transcriptomics, and theoretical modeling, we aim to capture the complexity of human cortical circuits in both in vitro and in vivo systems. These models enable us to investigate the balance between excitatory and inhibitory neurons and understand how disruptions to this balance contribute to NDDs.

Our current work focuses on integrating human cortical organoids and forebrain assembloids into rodent sensory cortex to establish functional human circuits in vivo. This approach bridges the gap between human-specific brain development and accessible experimental models.

Much of our research is collaborative and interdisciplinary, leveraging insights from genetics, developmental neurobiology, and systems neuroscience. Through these efforts, we aim to uncover the circuit-level mechanisms behind NDDs and lay the groundwork for developing novel therapeutic strategies. Our broader goal is to advance the understanding of human brain development and function to improve outcomes for those affected by neurological conditions.