Research
We are interested in the functional and molecular basis of neurodevelopmental disorders, such as autism spectrum disorders, epilepsy and intellectual disability, and in how these disorders manifest on the cellular and circuit levels of the developing brain. The lab implements molecular and physiological tools and uses human induced pluripotnt stem cells (hiPSCs) and other mammalian models to answer fundamental questions in neuropsychiatry
Specific research interests
Formation of early cortical networks and maturation of cortical neurons
Cortical cellular diversity and architecture
Signatures of neurodevelopmental and autism-related disorders
Transcriptional specification programs associated with neuronal development
Genetics of sociability in canines
Our methods
Human stem cells reprogramming and differentiation
Generation and transplantation of human cortical organoids
Patch clamp electrophysiology
Multi Electrode Array recordings
Single nuclei RNA sequencing
CRISPR cloning